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Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mix 2.5% pet
Author(s) -
Paulsen Evy,
Andersen Klaus E.
Publication year - 2019
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13346
Subject(s) - sensitization , medicine , parthenolide , sesquiterpene , allergy , sesquiterpene lactone , dermatology , contact allergy , allergic contact dermatitis , contact dermatitis , immunology , stereochemistry , biology , chemistry , apoptosis , biochemistry
Background Compositae contact sensitization may be difficult to diagnose, because of a lack of reliable screening allergens. Objectives To assess the suitability of Compositae mix II 2.5% pet. (CM2.5) as a screening mix in the baseline series combined with sesquiterpene lactone (SL) mix and parthenolide (PTH). Methods CM2.5 was added to the baseline series, which included SL mix and PTH 0.1% pet., in January 2015, and PTH was included in TRUE Test Panel 3 in October 2015. All Compositae‐sensitive patients diagnosed or tested in the next 4 years were assessed. Results Altogether, 57 patients (2.7%) presented with Compositae allergy. On primary testing in 53 newly diagnosed patients, SL mix elicited positive reactions most frequently (53% positive), followed by CM2.5 (47% positive), and PTH (45% positive). CM2.5 and PTH pet. elicited a few irritant reactions. Three patients had late reactions. Altogether, 16 patients (28%) were not detected by any of the three screening agents. Conclusions SL mix is an indispensable, although insufficient, screening mixture in Denmark. It may be relatively safely supplemented with CM2.5 and PTH in the TRUE Test system for screening, but, when Compositae sensitization is suspected, further extracts should be tested on the basis of the history.