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Evaluation of risk modification for p ‐phenylenediamine sensitization by N ‐acetyltransferase 1 and 2 for two highly sensitive cases
Author(s) -
Schuttelaar Marie L. A.,
van Amerongen Cynthia C. A.,
Lichter Jutta,
Blömeke Brunhilde
Publication year - 2019
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13260
Subject(s) - hair dyes , dermatology , allergic contact dermatitis , scalp , erythema , dyeing , contact dermatitis , medicine , allergy , itching , sensitization , black hair , chemistry , immunology , biology , genetics , organic chemistry
p-Phenylenediamine (PPD, 1,4-diaminobenzene, CAS no. 106-50-3) is well known as key allergen in hair dye-related allergic contact dermatitis. PPD can be N-acetylated to the non-sensitizing compounds mono- (MAPPD) and diacetyl-PPD (DAPPD) by N-acetyltransferase 1 (NAT1) in keratinocytes , and outside the skin also by N-acetyltransferase 2 (NAT2). Investigating the elicitation response modification by N-acetyltransferase 1 and 2 genotypes we showed that genotypes containing the rapid acetylator NAT1*10 allele and individuals homozygous for the rapid acetylator allele NAT2*4 were under-represented in PPD-sensitized cases. Here we evaluated this finding by investigation of two well-characterized highly sensitive cases with a longstanding history of allergic contact dermatitis to dyes. This article is protected by copyright. All rights reserved.