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p-Phenylenediamine (PPD, 1,4-diaminobenzene, CAS no. 106-50-3) is well known as key allergen in hair dye-related allergic contact dermatitis. PPD can be N-acetylated to the non-sensitizing compounds mono- (MAPPD) and diacetyl-PPD (DAPPD) by N-acetyltransferase 1 (NAT1) in keratinocytes , and outside the skin also by N-acetyltransferase 2 (NAT2). Investigating the elicitation response modification by N-acetyltransferase 1 and 2 genotypes we showed that genotypes containing the rapid acetylator NAT1*10 allele and individuals homozygous for the rapid acetylator allele NAT2*4 were under-represented in PPD-sensitized cases. Here we evaluated this finding by investigation of two well-characterized highly sensitive cases with a longstanding history of allergic contact dermatitis to dyes. This article is protected by copyright. All rights reserved.

Evaluation of risk modification for p ‐phenylenediamine sensitization by N ‐acetyltransferase 1 and 2 for two highly sensitive cases