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Allergic contact dermatitis caused by calcipotriol
Author(s) -
Gilissen Liesbeth,
Huygens Sara,
Goossens An
Publication year - 2018
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12910
Subject(s) - calcipotriol , medicine , dermatology , patch test , contact dermatitis , allergic contact dermatitis , allergy , contact allergy , isopropyl alcohol , psoriasis , irritant contact dermatitis , immunology , chemistry , organic chemistry
Summary Background Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. Objectives To report on 6 patients (among them an 11‐year‐old child) who presented with eczematous lesions complicating pre‐existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. Methods Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines. Results Allergic contact dermatitis was confirmed in all cases, and the lesions improved following treatment with topical corticosteroids and/or oral medication. Conclusions When topical treatment with calcipotriol fails to improve, or even worsens, existing skin lesions, contact allergy should be suspected. A patch test concentration of 2 µg/ml in isopropyl alcohol seems to be the most suitable. According to the literature, patients sensitized to calcipotriol may tolerate topical therapy with other vitamin D 3 analogues, particularly tacalcitol.