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Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin
Author(s) -
Li Zhengxiao,
Hu Lizhi,
Elias Peter M.,
Man MaoQiang
Publication year - 2018
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12909
Subject(s) - transepidermal water loss , stratum corneum , sensitive skin , dermatology , skin care , medicine , barrier function , dry skin , skin reaction , epidermis (zoology) , pathology , biology , anatomy , nursing , microbiology and biotechnology
Summary Background Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin. Objective To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin. Methods Following topical applications of individual vehicle or skin care product to C 57 BL /6 J mice twice daily for 4 days, transepidermal water loss ( TEWL ) rates, stratum corneum ( SC ) hydration and skin surface p H were measured on treated versus untreated mouse skin with an MP A5 device and p H 900 p H meter. Results Our results show that all tested products induced abnormalities in epidermal functions of varying severity, including elevations in TEWL and skin surface p H , and reduced SC hydration. Conclusions Our results suggest that mice can serve as a predictive model that could be used to evaluate the potential safety of skin care products in humans with sensitive skin.