Premium
Patch testing in non‐immediate cutaneous adverse drug reactions: value of extemporaneous patch tests
Author(s) -
Assier Haudrey,
ValeyrieAllanore Laurence,
Gener Gwendeline,
Verlinde Carvalh Muriel,
Chosidow Olivier,
Wolkenstein Pierre
Publication year - 2017
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12842
Subject(s) - medicine , patch testing , drug reaction , drug , patch test , culprit , surgery , dermatology , adverse drug reaction , adverse effect , contact dermatitis , pharmacology , allergy , myocardial infarction , immunology
Summary Background Patch testing following a standardized protocol is reliable for identifying the culprit drug in cutaneous adverse drug reactions ( CADR s). However, these patch tests ( PTs ) require pharmaceutical material and staff, which are not always easily available. Objectives To evaluate an extemporaneous PT method in CADRs . Methods We retrospectively analysed data for all patients referred to our department between M arch 2009 and J une 2013 for patch testing after a non‐immediate CADR . The patients who supplied their own suspected drugs were tested both with extemporaneous PTs and with conventional PT s. Extemporaneous PTs involved a nurse crushing and diluting the drug in pet. in a ratio of approximately one‐third to two‐thirds. Standardized PTs were performed according to guidelines, with commercial drugs diluted to 30% or with active ingredients diluted to 10%. We analysed the data for the two PT methods in terms of the number of positive test reactions, drugs tested, and type of CADR for patients in whom the two PT methods were used. Results In total, 75 of 156 patients underwent the two PT procedures, including 91 double tests. Overall, 21 tests gave positive reactions with the two methods, and 69 other tests gave negative results with the two methods. Conclusion Our series yielded results similar to those of published series concerning the types of CADR and the drugs responsible. Our results suggest that, for CADR s, if a patient supplies a suspected drug but if the pharmaceutical material and staff are not available for conventional PT s, extemporaneous PT s performed by the nurse with the commercial drug used by the patient can be useful and reliable.