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Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
Author(s) -
Koppes Sjors A.,
Engebretsen Kristiane A.,
Agner Tove,
AngelovaFischer Irena,
Berents Teresa,
Brandner Johanna,
Brans Richard,
Clausen MajaLisa,
Hummler Edith,
Jakasa Ivone,
JurakićTončic Ružica,
John Swen M.,
Khnykin Denis,
Molin Sonja,
Holm Jan O.,
Suomela Sari,
Thierse HermannJosef,
Kezic Sanja,
Martin Stefan F.,
Thyssen Jacob P.
Publication year - 2017
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12789
Subject(s) - allergic contact dermatitis , sensitization , medicine , atopic dermatitis , dermatology , immunology , contact dermatitis , allergy , irritant contact dermatitis , population , environmental health
Summary Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non‐systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.