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Lack of differentiation of allergic and irritant reactions by skin autofluorescence
Author(s) -
Shin Eun Jae,
Gwak Min Jae,
Jeong Ki Heon,
Shin Min Kyung
Publication year - 2017
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12708
Subject(s) - medicine , dermatology
Contact dermatitis is an inflammatory eczematous skin disease that is mostly caused by chemicals or metal ions that exert toxic effects without inducing a T cell response (contact irritants), or by small reactive chemicals that modify proteins and induce innate and adaptive immune responses (contact allergens) (1). Differentiation of acute allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) is important in order to ensure proper therapeutic and management strategies. Several non-invasive methods, based on various physical principles, have been used in research to distinguish between allergic and irritant reactions. Among these, reflectance confocal microscopy (RCM) has been shown to be a promising tool for the differentiation of acute ACD and ICD in vivo (2).