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Patch testing with hydroxyisohexyl 3‐cyclohexene carboxaldehyde ( HICC ) – a multicentre study of the S wedish C ontact D ermatitis R esearch G roup
Author(s) -
Engfeldt Malin,
Hagvall Lina,
Isaksson Marléne,
Matura Mihály,
Mowitz Martin,
Ryberg Kristina,
Stenberg Berndt,
Svedman Cecilia,
Bruze Magnus
Publication year - 2017
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12699
Subject(s) - patch testing , concomitant , medicine , contact dermatitis , allergic contact dermatitis , patch test , allergy , contact allergy , sensitization , dermatology , chemistry , immunology , surgery
Summary Background In 2014, the fragrance hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series. Objectives To study (i) whether fragrance mix ( FM ) II with 5% HICC detects more positive reactions than usual FM II with 2.5% HICC , and (ii) the reproducibility of patch testing with HICC . Methods Two thousand one hundred and eighteen dermatitis patients at five S wedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet. Results Of the patients, 3.2% reacted to FM II 14%, and 1.5% reacted to HICC . Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II . FM II with 5% HICC did not give rise to more irritant reactions or signs of active sensitization than FM II with 2.5% HICC . Patch testing with duplicate applications of HICC increased the overall prevalence of HICC contact allergy to 1.9%. Conclusion FM II with 5% HICC does not detect more positive reactions than FM II with 2.5% HICC . Separate testing with HICC does not detect a sufficient proportion of patients who react only to HICC , without concomitant reactions to FM II , to warrant its inclusion in a baseline series.