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Occupational opiate contact dermatitis
Author(s) -
Colomb Sophie,
Bourrain Jean L.,
Bonardel Nathalie,
Chiriac Anca,
Demoly Pascal
Publication year - 2017
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12666
Subject(s) - medicine , humanities , library science , art , computer science
Two female laboratory workers aged 38 and 58 years were employed for 18 and 7 months, respectively, in a pharmaceutical company that manufactures several opiates. Both handled morphine and codeine. The first one also worked with dihydrocodeine, and the second one with naltrexone. Both developed papulovesicular contact dermatitis with an airborne pattern. Patch tests were performed according to ICDRG criteria (2), with the products from the plant at different concentrations (0.01–5% or 10%) in pet. and aq., respectively. The products tested were morphine, codeine, thebaine, ethylmorphine, naloxone, and oxycodone. Prick and intradermal tests were also performed with synthetic products such as alfentanil, sufentanil, fentanyl, and tramadol. All substances tested in water gave negative results (0.01–10%). Both cases showed positive patch test reactions to codeine 5% pet. (+), which was still positive on D9 for case 2, and ethylmorphine 1% and 10% pet. (+). Case 1 also showed positive patch test reactions to morphine [(+) for a 0.1% dilution and (++) for higher