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Concomitant contact allergies to formaldehyde, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, and fragrance mixes I and II
Author(s) -
Pontén Ann,
Bruze Magnus,
Engfeldt Malin,
Hauksson Inese,
Isaksson Marléne
Publication year - 2016
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12598
Subject(s) - contact allergy , allergy , dermatology , cosmetics , allergic contact dermatitis , formaldehyde , contact dermatitis , medicine , chemistry , organic chemistry , immunology
Summary Background Contact allergies to the preservatives formaldehyde and methylchloroisothiazolinone ( MCI )/methylisothiazolinone ( MI ) have been reported to appear together at a statistically significant level. Recently, revisions concerning the patch test preparations of MCI / MI , MI and formaldehyde have been recommended for the E uropean baseline series. Aim To investigate (i) the number of concomitant contact allergies to the preservatives, (ii) the number of concomitant contact allergies to the preservatives and the fragrance mixes (FM I and FM II) and (iii) gender differences. Methods Patients tested with the S wedish baseline series during the period 2012–2014 at the D epartment of O ccupational and E nvironmental D ermatology in M almö, S weden were investigated. Results 2165 patients were patch tested with the baseline series (34% males and 66% females). Contact allergies to formaldehyde and MCI / MI and/or MI were significantly associated ( p < 0.001). The associations between contact allergy to MCI / MI and/or MI and FM I and/or FM II , and between formaldehyde and FM I and/or FM II as well as, were statistically significant ( p < 0.001). Conclusion Contact allergies to formaldehyde and MCI / MI and/or MI are significantly associated, as well as contact allergies to these preservatives and fragrance allergy. Males and females do not differ significantly concerning contact allergy to fragrances.