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Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002–2011. Part II : concomitant reactions
Author(s) -
Geier Johannes,
Lessmann Holger,
Hillen Uwe,
Skudlik Christoph,
Jappe Uta
Publication year - 2016
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12490
Subject(s) - diluent , reactivity (psychology) , chemistry , epoxy , diglycidyl ether , sensitization , ether , organic chemistry , polymer chemistry , medicine , immunology , bisphenol a , alternative medicine , pathology
Summary Background Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems ( ERS s). Because of chemical similarities, immunological cross‐reactivity may occur. Objectives To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERS s ( FP ‐0324). Methods A retrospective analysis of data from the I nformation N etwork of D epartments of D ermatology ( IVDK ), 2002–2011, was performed. Results There was close concomitant reactivity to 1,6‐hexanediol diglycidyl ether and 1,4‐butanediol diglycidyl ether (1,4‐ BDDGE ), and to phenyl glycidyl ether ( PGE ) and cresyl glycidyl ether ( CGE ), whereas reactions to p ‐tert‐butylphenyl glycidyl ether occurred more independently from those to PGE and CGE . Concomitant reactions to butyl glycidyl ether and 1,4‐ BDDGE may point to a common allergenic compound derived from the metabolism of 1,4‐ BDDGE . Among the structurally more diverse group of hardeners, there was no evidence of immunological cross‐reactions. Conclusions More detailed knowledge of cross‐reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERS s to be composed in the future.