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Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I
Author(s) -
Geier Johannes,
Schnuch Axel,
Lessmann Holger,
Uter Wolfgang
Publication year - 2015
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12468
Subject(s) - reactivity (psychology) , patch test , patch testing , chemistry , contact dermatitis , medicine , allergy , immunology , pathology , alternative medicine
Summary Background Fragrance mix I ( FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate ( SSO ), respectively. SSO is a rare sensitizer and a potential irritant. Objectives To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO . Methods A retrospective analysis of data from the I nformation N etwork of D epartments of D ermatology, 1998–2013, was performed. Results The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO ‐positive patients, who also had more multiple reactions than FM I ‐positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances). Conclusions Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.