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Immediate hypersensitivity caused by cetylpyridinium chloride in a throat spray
Author(s) -
Shima Kaori,
Tanizaki Hideaki,
Endo Yuichiro,
Fujisawa Akihiro,
Tanioka Miki,
Miyachi Yoshiki,
Kabashima Kenji
Publication year - 2015
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12418
Subject(s) - dermatology , medicine
A 67-year-old male frequently consumed throat lozenges and used throat sprays. One day, he experienced cold-like symptoms and began to take some prescription medicine (loxoprofen sodium, rebamipide, tranexamic acid, cloperastine, and cefcapene pivoxil hydrochloride). Twenty minutes after using the throat spray, he developed generalized wheals, swelling of the eyelids and lips, and dyspnoea. He received systemic corticosteroid therapy and recovered. We suspected that the immediate hypersensitivity occurred because of the medicine or the throat spray. The throat spray contained glycerol, propylene glycol, D-sorbitol, ethanol, l-menthol, citric acid, sodium citrate, and CPC. To identify the allergenic drugs, we performed a drug lymphocyte stimulation test for loxoprofen sodium and cefcapene pivoxil hydrochloride, as these are known common allergens; however, the results were negative for both drugs. The patient had no previous history of non-steroidal anti-inflammatory drug intolerance.