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Pustular allergic contact dermatitis caused by fragrances
Author(s) -
Verma Amit,
Tancharoen Chasari,
Tam Mei M.,
Nixon Rosemary
Publication year - 2015
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12341
Subject(s) - contact dermatitis , medicine , dermatology , allergic contact dermatitis , allergy , immunology
Pustular allergic contact dermatitis (ACD) is rare, with reactions to the topical antibacterial nitrofurazone (1), isoconazole nitrate (2), topical minoxidil 2% (3), 1% fluorouracil (4), black rubber (5) and tricholoroethylene (6) having been reported. The clinical appearance of pustular ACD has been reported to comprise multiple small pustules, only 0.5–1 mm in size, on a background of erythema and swelling, and the condition is associated with marked pruritus. Histologically, there are features consistent with ACD (epidermal spongiosis, dermal oedema, and perivascular mononuclear infiltrate), in addition to epidermal pustules composed of lymphocytes and occasional neutrophils (7). Cultures of the pustules must be sterile for a diagnosis of pustular ACD to be made, and the condition must also be distinguished from the more common conditions pustular psoriasis and acute generalized exanthematous pustulosis (AGEP). A case is reported of an elderly man who presented with both eczematous and pustular rashes, and who showed multiple eczematous and pustular patch test reactions.