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Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five E uropean countries
Author(s) -
Schwensen Jakob F.,
Lundov Michael D.,
Bossi Rossana,
Banerjee Piu,
GimenezArnau Elena,
Lepoittevin JeanPierre,
Lidén Carola,
Uter Wolfgang,
Yazar Kerem,
White Ian R.,
Johansen Jeanne D.
Publication year - 2015
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12322
Subject(s) - contact allergy , medicine , allergy , contact dermatitis , immunology
Summary Background In view of the current epidemic of contact allergy to methylisothiazolinone ( MI ), it is important to clarify the extent of use of MI and related isothiazolinones in paints currently available for the consumer and worker in E urope. Objectives To elucidate the use and concentrations of MI , methylchloroisothiazolinone ( MCI ) and benzisothiazolinone ( BIT ) in paints on the E uropean retail market. Methods Wall paints (n = 71) were randomly purchased in retail outlets in five E uropean countries. The paints were quantitatively analysed for their contents of MI , MCI and BIT by high‐performance liquid chromatography coupled to tandem mass spectrometry. Results MI was found in 93.0% (n = 66) of the paints, with concentrations ranging from 0.7 to 180.9 ppm, MCI in 23.9% (n = 17), ranging from 0.26 to 11.4 ppm, and BIT in 95.8% (n = 68), ranging from 0.1 to 462.5 ppm. High concentrations of MI were found in paints from all five countries. Paints purchased in D enmark and S weden contained especially high concentrations of BIT . Conclusion The use of MI across E uropean countries is extensive. In view of the ongoing epidemic of MI contact allergy, an evaluation of the safety of MI in paints is needed.