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Patch testing with a textile dye mix – a multicentre study
Author(s) -
Ryberg Kristina,
Agner Tove,
Andersen Klaus E.,
Bircher Andreas,
Diepgen Thomas,
Foti Caterina,
GiménezArnau Ana,
Gonçalo Margarida,
Goossens An,
Johansen Jeanne D.,
Le Coz Christophe,
Maibach Howard I.,
Bruze Magnus
Publication year - 2014
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12244
Subject(s) - contact allergy , medicine , patch test , allergy , dermatology , contact dermatitis , allergic contact dermatitis , patch testing , allergen , p phenylenediamine , immunology , materials science , composite material
Summary Background Disperse dyes are well‐known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series. Objectives To investigate the outcome of patch testing with a textile dye mix ( TDM ) consisting of eight disperse dyes at dermatology clinics in various countries. Patients/materials/methods Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of D isperse B lue 35, D isperse Y ellow 3, D isperse O range 1 and 3, and D isperse R ed 1 and 17, all at 1.0%, and D isperse B lue 106 and D isperse B lue 124, each at 0.3%, provisionally included in the baseline series. Eighty‐seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes. Results Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p ‐phenylenediamine was found in 57 of the TDM ‐positive patients (53%). The most frequent dye allergen among the TDM ‐positive patients was D isperse O range 3. The contact allergy could have explained or contributed to the dermatitis in approximately one‐third of the patients for whom clinical relevance of the TDM contact allergy was recorded. Conclusions The TDM should be considered for inclusion in the E uropean baseline series.