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Isothiazolinones in commercial products at D anish workplaces
Author(s) -
Friis Ulrik Fischer,
Menné Torkil,
Flyvholm MariAnn,
Bonde Jens Peter Ellekilde,
Lepoittevin JeanPierre,
Le Coz Christophe J.,
Johansen Jeanne Duus
Publication year - 2014
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12235
Subject(s) - product (mathematics) , skin type , medicine , toxicology , dermatology , mathematics , biology , geometry
Summary Background In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several E uropean countries. Objective To examine the extent and occurrence of isothiazolinones in different types of product at D anish workplaces. Methods Seven different isothiazolinones were identified in the D ictionary of C ontact A llergens: C hemical S tructures, S ources, and R eferences from K anerva's O ccupational D ermatitis . By use of the chemical names and C hemical A bstracts S ervice numbers for these chemicals, information on products registered in the D anish P roduct R egister Database ( PROBAS ) was obtained. Results All seven isothiazolinones were registered in PROBAS . The top three isothiazolinones registered were: benzisothiazolinone ( BIT ), registered in 985 products, methylisothiazolinone ( MI ), registered in 884 products, and methylchloroisothiazolinone (MCI)/MI, registered in 611 products. The concentration ranges were 0.01 ppm to 45% for BIT , 0.01 ppm to 10% for MI , and 0.01 ppm to 14.1% for MCI / MI . The most common product type was ‘paint and varnish’; five of the seven isothiazolinones were registered in this type of product. Conclusion Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.