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Parthenium dermatitis: is parthenolide an effective choice for patch testing?
Author(s) -
Mahajan Vikram K.,
Sharma Vikas,
Gupta Mrinal,
Chauhan Pushpinder S.,
Mehta Karaninder S.,
Garg Swati
Publication year - 2014
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12194
Subject(s) - parthenolide , parthenium , parthenium hysterophorus , medicine , dermatology , erythema , patch test , contact dermatitis , allergy , immunology , chemistry , biology , botany , apoptosis , biochemistry , weed
Summary Background Patch test positivity to parthenolide was observed less often than expected in strongly suspected cases of parthenium dermatitis after C hemotechnique D iagnostics ( S weden) replaced parthenium extract with parthenolide (0.5% pet.) by itself while marketing its Indian baseline series for patch testing. Objective The study was performed to find whether parthenolide detects parthenium contact sensitivity more effectively than parthenium extract in patients clinically presenting with classic parthenium dermatitis. Material and methods One hundred consecutive patients with suspected parthenium dermatitis were patch tested prospectively with the Indian baseline series, parthenium extract (1% aq.) and parthenolide (0.5% pet.) between July 2011 and April 2012. Results Only 37 of 100 patients with suspected parthenium dermatitis (male/female ratio of 20:17) reacted to parthenium extract (32 patients), parthenolide (17 patients), or both (12 patients). Reactions to parthenium extract were generally stronger than reactions to parthenolide. Conclusion Patch testing with parthenolide (0.5% pet.) detects fewer cases of suspected parthenium dermatitis than patch testing with parthenium extract (1% aq.).