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Baseline series fragrance markers fail to predict contact allergy
Author(s) -
Mann Jack,
McFadden John P.,
White Jonathan M. L.,
White Ian R.,
Banerjee Piu
Publication year - 2014
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12171
Subject(s) - isoeugenol , contact allergy , allergy , patch test , contact dermatitis , allergic contact dermatitis , patch testing , allergen , dermatology , medicine , chemistry , organic chemistry , immunology , eugenol
Summary Background Negative patch test results with fragrance allergy markers in the E uropean baseline series do not always predict a negative reaction to individual fragrance substances. Objectives To determine the frequencies of positive test reactions to the 26 fragrance substances for which labelling is mandatory in the EU , and how effectively reactions to fragrance markers in the baseline series predict positive reactions to the fragrance substances that are labelled. Methods The records of 1951 eczema patients, routinely tested with the labelled fragrance substances and with an extended E uropean baseline series in 2011 and 2012, were retrospectively reviewed. Results Two hundred and eighty‐one (14.4%) (71.2% females) reacted to one or more allergens from the labelled‐fragrance substance series and/or a fragrance marker from the E uropean baseline series. The allergens that were positive with the greatest frequencies were cinnamyl alcohol (48; 2.46%), Evernia furfuracea (44; 2.26%), and isoeugenol (40; 2.05%). Of the 203 patients who reacted to any of the 26 fragrances in the labelled‐fragrance substance series, only 117 (57.6%) also reacted to a fragrance marker in the baseline series. One hundred and seven (52.7%) reacted to either fragrance mix I or fragrance mix II , 28 (13.8%) reacted to Myroxylon pereirae , and 13 (6.4%) reacted to hydroxyisohexyl 3‐cyclohexene carboxaldehyde. Conclusions These findings confirm that the standard fragrance markers fail to identify patients with contact allergies to the 26 fragrances.