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Recommendation to include methylisothiazolinone in the E uropean baseline patch test series – on behalf of the E uropean S ociety of C ontact Dermatitis and the E uropean E nvironmental and C ontact D ermatitis R esearch G roup
Author(s) -
Bruze Magnus,
Engfeldt Malin,
Gonçalo Margarida,
Goossens An
Publication year - 2013
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12150
Subject(s) - patch test , contact allergy , medicine , contact dermatitis , allergic contact dermatitis , allergy , dermatology , cosmetics , preservative , patch testing , surgery , food science , chemistry , immunology , pathology
Summary Background Methylisothiazolinone ( MI ) is used as a preservative in occupational and household products, and cosmetics. It is a part of the preparation of methylchloroisothiazolinone ( MCI )/ MI , which is patch tested in water in the European baseline series. However, this preparation fails to detect a significant percentage of allergic contact reactions to MI . Objectives To investigate whether a separate test preparation with MI should be included in the European baseline series. Methods Literature survey. Results In consecutively tested dermatitis patients, the contact allergy rate for MI varies between 0.6% and 6%, with a marked increase in recent years. The contact allergy rate for MI alone, not detected with MCI / MI , varies between 0% and 1.6%. Most cases are relevant, as shown by repeated open application test studies, and are mainly related to exposure from cosmetic products. Conclusions Owing to the increase in contact allergy to MI not detected with MCI / MI , it is recommended that MI in water at 2000 ppm be included in the European baseline series. With the Finn Chamber ® (diameter, 8 mm) technique, a volume of 15 µl should be applied, giving a dose of 60 µg/cm 2 .