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Filaggrin loss‐of‐function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study
Author(s) -
Visser Maaike J.,
Verberk Maarten M.,
Campbell Linda E.,
McLean W. H. Irwin,
Calkoen Florentine,
Bakker Jan G.,
van Dijk Frank J. H.,
Bos Jan D.,
Kezic Sanja
Publication year - 2014
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12139
Subject(s) - hand eczema , atopic dermatitis , filaggrin , medicine , dermatology , odds ratio , family history , atopy , risk factor , allergy , moisturizer , immunology , contact dermatitis , biology , food science
Summary Background/objectives Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss‐of‐function mutations in the filaggrin gene ( FLG ), atopic dermatitis and wet work exposure on the development of hand eczema in apprentice nurses. Methods Dutch apprentice nurses were genotyped for the four most common FLG mutations; atopic dermatitis and hand eczema history were assessed by questionnaire. Exposure and hand eczema during traineeships were assessed with diary cards. Results The prevalence of hand eczema during traineeships was higher among subjects with a history of hand eczema reported at inclusion. Hand washing during traineeships and at home increased the risk of hand eczema. After adjustment for the effects of exposure and FLG mutations, an odds ratio of 2.5 (90% confidence interval 1.7–3.7) was found for a history of atopic dermatitis. In this study, an increased risk of hand eczema conferred by FLG mutations could not be shown, but subjects with concomitant FLG mutations and atopic dermatitis showed the highest risk of hand eczema during traineeships. Conclusion A history of atopic dermatitis, a history of hand eczema and wet work exposure were the most important factors increasing the risk of hand eczema during traineeships.