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Risk factors associated with sensitization to hydroxyisohexyl 3‐cyclohexene carboxaldehyde
Author(s) -
Uter Wolfgang,
Geier Johannes,
Schnuch Axel,
Gefeller Olaf
Publication year - 2013
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.12069
Subject(s) - sensitization , odds ratio , medicine , allergic contact dermatitis , allergy , logistic regression , allergen , dermatology , risk factor , confidence interval , contact dermatitis , patch testing , contact allergy , demography , immunology , sociology
Summary Background Hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) is a synthetic fragrance chemical and an important contact allergen, at least in Europe. Despite this importance, little is known about risk factors associated with this allergen. Objective To examine factors from the history and clinical presentation of patch tested patients associated with HICC sensitization. Methods Contact allergy surveillance data of 95 637 patients collected by the Information Network of Departments of Dermatology (IVDK, www.ivkd.org ) in 2002–2011 were analysed. Point and interval estimates of the relative risk were derived from multifactorial logistic regression modelling. Results The overall prevalence of HICC sensitization was 2.24%. The strongest risk factors were polysensitization and dermatitis of the axillae, followed by dermatitis at other sites. No consistent and significant time trend was observed in this analysis. As compared with the youngest patients, the odds of HICC sensitization increased approximately three‐fold in the 52–67‐year age group, and strongly declined with further increasing age. Conclusions The risk pattern with regard to age and affected anatomical site differed from that observed with other fragrance screening allergens. Cosmetic exposure, as broadly defined here, was a stronger and more prevalent individual risk factor than occupational exposure.