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Changes in health‐related quality of life with intensive behavioural therapy combined with liraglutide 3.0 mg per day
Author(s) -
Chao Ariana M.,
Wadden Thomas A.,
Walsh Olivia A.,
Gruber Kathryn A.,
Alamuddin Naji,
Berkowitz Robert I.,
Tronieri Jena S.
Publication year - 2019
Publication title -
clinical obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 12
eISSN - 1758-8111
pISSN - 1758-8103
DOI - 10.1111/cob.12340
Subject(s) - liraglutide , medicine , quality of life (healthcare) , weight loss , body mass index , obesity , distress , body weight , physical therapy , diabetes mellitus , endocrinology , clinical psychology , type 2 diabetes , nursing
Summary This study examined the effects of intensive behavioural therapy (IBT) for obesity (IBT‐alone), IBT plus liraglutide 3.0 mg/day (IBT‐liraglutide), and IBT‐liraglutide combined with 12 weeks of a portion‐controlled diet (Multicomponent) on changes in general health‐related (HR) quality of life (QoL) and weight‐related QoL. Adults with obesity (79.3% female; 54.0% white; 44.7% black; mean age = 47.6 ± 11.8 years and body mass index = 38.4 ± 4.9 kg/m 2 ) were randomized to IBT‐alone (n = 50), IBT‐liraglutide (n = 50) or Multicomponent (n = 50). General HRQoL was measured with the Short Form‐36 (SF‐36), and weight‐related QoL was assessed with the Impact of Weight on Quality of Life‐Lite scale. At week 52, participants in the three groups lost 6.1 ± 1.3%, 11.5 ± 1.3% and 11.8 ± 1.3% of initial body weight, respectively. Both liraglutide‐treated groups were significantly more likely than IBT‐alone to achieve clinically meaningful improvements in total weight‐related QoL. They also both achieved greater improvements than IBT‐alone in weight‐related public distress and in general mental health, as measured by the SF‐36 mental component summary score. Independent of treatment group, greater categorical weight loss was associated with greater improvements in several domains of both general and weight‐related QoL. The addition of liraglutide to IBT appeared to improve aspects of both general HRQoL and weight‐related QoL.