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A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion‐ and stress‐related eating, food cravings and appetite
Author(s) -
Chao A. M.,
Wadden T. A.,
Pearl R. L.,
Alamuddin N.,
Leonard S. M.,
Bakizada Z. M.,
Pinkasavage E.,
Gruber K. A.,
Walsh O. A.,
Berkowitz R. I.,
Alfaris N.,
Tronieri J. S.
Publication year - 2018
Publication title -
clinical obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 12
eISSN - 1758-8111
pISSN - 1758-8103
DOI - 10.1111/cob.12279
Subject(s) - emotional eating , appetite , medicine , placebo , binge eating , weight loss , randomization , dieting , obesity , randomized controlled trial , clinical psychology , eating behavior , alternative medicine , pathology
Summary Anti‐obesity medication may help people maintain diet‐induced reductions in appetite. The present exploratory analysis assessed the effects of lorcaserin on changes at 24 weeks post‐randomization in emotion‐ and stress‐related eating, food cravings and other measures of appetite (i.e. binge eating, cognitive restraint, disinhibition, hunger, preoccupation with eating and fullness). The parent study investigated the efficacy of combined lorcaserin and behavioural treatment in facilitating weight loss maintenance (WLM) in 137 adults (mean age = 46.1 years, 86.1% female, 68.6% black) who had lost ≥5% of initial weight during a 14‐week, low‐calorie diet (LCD) run‐in. Participants were randomly assigned to lorcaserin or placebo and were provided with group WLM counselling sessions. Emotion‐ and stress‐related eating, food cravings and appetite were measured at the start of the LCD (week −14), randomization (0) and week 24. From randomization, lorcaserin‐treated participants had significantly greater improvements in emotion‐ and stress‐related eating compared to placebo‐treated participants ( P = 0.04). However, groups did not differ significantly after randomization in changes in the frequency of food cravings, binge eating or other measures of appetite ( P s > 0.05). Compared to placebo, lorcaserin may improve emotion‐ and stress‐related eating.