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Can we reconcile ‘the obesity paradox’ with recent cardiovascular outcome trials in diabetes?
Author(s) -
Jamieson A.,
Finer N.
Publication year - 2017
Publication title -
clinical obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 12
eISSN - 1758-8111
pISSN - 1758-8103
DOI - 10.1111/cob.12217
Subject(s) - medicine , cardiovascular health , gerontology , family medicine , library science , disease , computer science
Recent cardiovascular (CV) outcome trials of treatments for type 2 diabetes mellitus (T2DM) including Glucagonlike peptide-1 (GLP-1) receptor agonists (1,2) and sodiumglucose co-transporter-2 (SGLT2) inhibitor (3) have shown beneficial effects on both CV outcomes and body weight. The so-called obesity paradox refers to the epidemiological inference that obesity, defined by a body mass index (BMI) >30 kg m, when compared to normal weight (probably incorrectly defined as a BMI of 18.5–25 kg m), is associated with ‘counterintuitive improved health in a variety of disease conditions, including cardiovascular disease’ (4)? Do the trial findings further undermine the belief in a paradox, and can they provide support for the benefits of intentional weight loss?