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Associations of objective physical activity with insulin sensitivity and circulating adipokine profile: the Framingham Heart Study
Author(s) -
Spartano N. L.,
Stevenson M. D.,
Xanthakis V.,
Larson M. G.,
Andersson C.,
Murabito J. M.,
Vasan R. S.
Publication year - 2017
Publication title -
clinical obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.64
H-Index - 12
eISSN - 1758-8111
pISSN - 1758-8103
DOI - 10.1111/cob.12177
Subject(s) - adipokine , medicine , sed , insulin resistance , endocrinology , leptin , systemic inflammation , insulin , inflammation , obesity
Summary The purpose of this study was to explore the relation of physical activity ( PA ) and sedentary time ( SED ) to insulin sensitivity and adipokines. We assessed PA and SED using Actical accelerometers and insulin resistance ( HOMA‐IR ) in 2109 participants (free of type 1 and 2 diabetes mellitus) from Framingham Generation 3 and Omni 2 cohorts (mean age 46 years, 54% women). Systemic inflammation (C‐reactive protein [ CRP ]) and circulating adipokines were measured 6 years earlier. Steps per day, moderate‐to‐vigorous PA ( MVPA ) and SED per wear time (% SED ) were predictor variables in multivariable regression analyses, with HOMA‐IR , CRP and circulating adipokines as outcome measures. We reported that higher MVPA and more steps per day were associated with lower HOMA‐IR , adjusting for % SED (β = −0.036, P = 0.002; β = −0.041, P = 0.005). Steps were inversely associated with CRP , but were directly associated with insulin‐like growth factor ( IGF )‐1 levels (β = −0.111, P = 0.002; β = 3.293, P = 0.007). % SED was positively associated with HOMA‐IR (β = 0.033, P < 0.0001), but non‐significant after adjusting for MVPA ( P = 0.13). % SED was associated with higher ratio of leptin/leptin receptor ( sOB ‐R) and higher adipocyte fatty acid‐binding protein ( FABP )4 (β = 0.096, P < 0.0001; β = 0.593, P = 0.002). Our findings suggest differential influences of PA vs. SED on metabolic pathways, with PA modulating insulin resistance and inflammation, whereas SED influences FABPs.