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Impedance‐pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study
Author(s) -
Bobin Francois,
Auregan Guy,
Muls Vinciane,
Cammaroto Giovanni,
Hans Stéphane,
Saussez Sven,
Lechien Jerome R.
Publication year - 2021
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13745
Subject(s) - medicine , laryngopharyngeal reflux , obstructive sleep apnea , reflux , gerd , epworth sleepiness scale , polysomnography , prospective cohort study , gastroenterology , throat , sleep apnea , apnea , surgery , disease
Objective To study the profile of patients with obstructive sleep apnoea syndrome (OSAS) and laryngopharyngeal reflux (LPR) at the hypopharyngeal‐oesophageal multichannel intraluminal impedance‐pH monitoring (HEMII‐pH) and to compare their reflux findings with LPR patients without OSAS. Design Prospective controlled study. Methods Patients with LPR and OSAS were prospectively recruited from August 2019 to June 2020. The profile of hypopharyngeal reflux events (HREs) of patients was studied through a breakdown of the HEMII‐pH findings over the 24 hours of testing. Reflux symptom score (RSS), and gastrointestinal and HEMII‐pH outcomes were compared between LPR patients and patients with LPR and OSAS. Multivariate analysis was used to study the relationship between reflux data and the following sleep outcomes: Apnea Hypopnea Index, Epworth Sleepiness Scale (ESS) and paradoxical sleep data. Results A total of 89 patients completed the study. There were 45 patients with LPR and 44 subjects with both OSAS and LPR. The numbers of upright and daytime HREs and the otolaryngological RSS were significantly higher in patients with LPR compared with those with OSAS and LPR. There was a significant positive association between RSS quality‐of‐life score and ESS ( P = .001). The occurrence of HREs in the evening was associated with higher ESS ( P = .015). Patients with OSAS, LPR and GERD had higher number of nocturnal HREs compared with those without GERD ( P = .001). Conclusion The presence of OSAS in LPR patients is associated with less severe HEMII‐pH and ear, nose and throat symptoms. There may have different OSAS patient profiles according to the occurrence of GERD.