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Prognostic value of the neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio and systemic immune‐inflammation index in patients with laryngeal squamous cell carcinoma
Author(s) -
Li Zhilin,
Qu Yi,
Yang Yang,
An Wei,
Li Shaoqing,
Wang Bin,
He Ying,
Li Jing,
Shao Qi,
Qin Lizheng
Publication year - 2021
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13689
Subject(s) - medicine , receiver operating characteristic , neutrophil to lymphocyte ratio , lymphocyte , gastroenterology , retrospective cohort study , immune system , oncology , systemic inflammation , inflammation , immunology
Objectives We aimed to determine the prognostic value of the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR) and systemic immune‐inflammation index (SII) in patients with laryngeal squamous cell carcinoma (LSCC). Design and setting A retrospective analysis of patients with LSCC was conducted in our hospitals. Clinical information, including age, sex, TNM classification and other demographic and clinical data, was acquired and analysed. Progression‐free survival (PFS) and overall survival (OS) were calculated and compared using the Kaplan‐Meier method and log‐rank test. Participants A total of 147 patients with LSCC were included. Results According to the receiver operating characteristic (ROC) curve, the optimal cut‐off points for NLR, PLR and SII were 1.88, 117.36 and 517.64. The analysis revealed NLR, PLR and SII to be independent predictors for OS and PFS ( P < .05). Conclusions Preoperative NLR, PLR and SII are promising prognostic predictors for patients with LSCC.