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A case‐control study of the association between sialolithiasis and osteoporosis
Author(s) -
Hung ShihHan,
Xirasagar Sudha,
Cheng YenFu,
Lin HerngChing
Publication year - 2019
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13310
Subject(s) - medicine , osteoporosis , odds ratio , confidence interval , logistic regression , case control study , pediatrics , physical therapy
Objective The purpose of this study was to evaluate the association between osteoporosis and salivary gland stone using a population‐based claims database. Design A case‐control design. Setting Taiwan. Participants We retrieved the sample for this case‐control study from the Taiwan “Longitudinal Health Insurance Database 2005.” All 557 patients aged 40 years or older with a diagnosis of sialolithiasis were cases, and 1671 matched controls (without sialolithiasis) were selected. Subjects and Methods We used the chi‐square test to explore differences between cases and controls on socio‐demographic characteristics. Furthermore, conditional logistic regressions were used to examine the association of sialolithiasis with previously diagnosed osteoporosis. Results Of 2228 sampled patients, 171 (7.68%) had ever been previously diagnosed with osteoporosis; 58 (10.41%) among cases and 113 (6.76%) among controls ( P = 0.005). Conditional logistic regression analysis found that the odds ratio (OR) of prior osteoporosis for cases was 1.79 (95% confidence interval [CI]: 1.24‐2.59, P = 0.002) relative to controls after adjusting for urbanisation and the selected medical co‐morbidities. Furthermore, we found that among patients aged ≥65 years, the adjusted OR of prior osteoporosis for cases was 1.89 (95% CI = 1.02‐3.51). No significant relationship was observed among patients aged <65 years old. Conclusion This study demonstrates an association between sialolithiasis and osteoporosis. Although the finding warrants further investigation, the results call for more awareness of the possible concurrence of osteoporosis among physicians and patients with salivary gland stones.