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Dysregulation of ß‐catenin, WISP1 and TCF21 predicts disease‐specific survival and primary response against radio(chemo)therapy in patients with locally advanced squamous cell carcinomas of the head and neck
Author(s) -
Vyskocil Erich,
Pammer Johannes,
Altorjai Gabriela,
Grasl Matthaeus Ch.,
Parzefall Thomas,
Haymerle Georg,
Janik Stefan,
Perisanidis Christos,
Erovic Boban M.
Publication year - 2019
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13281
Subject(s) - medicine , oncology , radiation therapy , stage (stratigraphy) , head and neck squamous cell carcinoma , disease , immunohistochemistry , chemoradiotherapy , retrospective cohort study , concomitant , proportional hazards model , head and neck cancer , paleontology , biology
Objective The objective of this study was to determine the prognostic and predictive impact of β‐catenin, TCF21 and WISP1 expression in patients with squamous cell carcinomas of the head and neck who underwent primary radiotherapy or concomitant chemoradiotherapy. Study design Prospective cohort study. Setting University hospital. Participants Protein expression profiles of β‐catenin, TCF21, WISP1 and p16 were determined by immunohistochemical analyses in tissue samples of 59 untreated patients. Expression was correlated with different outcome parameters. Main outcome measures Impact of TNM classification, grading, sex, age, gender, type of therapy, response to therapy and p16 status on disease‐specific (DSS) and disease‐free survival (DFS). Results Patients with high expression of TCF21 were associated with significantly worse disease‐specific survival ( P = 0.005). In a multivariable analysis, TCF21 was a significant determinant of disease‐specific survival. (HR 3.01; P = 0.036). Conversely, low expression of β‐catenin ( P = 0.025) and WISP1 ( P = 0.037) revealed a better response to radiotherapy. Conclusion Since data show that TCF21 is a prognostic factor for disease‐specific survival and WISP1 and ß‐catenin are predictive factors for clinical outcome after definitive radiotherapy, further studies are warranted to prove these preliminary but very promising findings.