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Survival differences in nasopharyngeal carcinoma among racial and ethnic minority groups in the United States: A retrospective cohort study
Author(s) -
Challapalli Sai D.,
Simpson Matthew C.,
Adjei Boakye Eric,
Walker Ronald J.,
Antisdel Jastin L.,
Ward Greg M.,
OsazuwaPeters Nosayaba
Publication year - 2019
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13225
Subject(s) - medicine , pacific islanders , nasopharyngeal carcinoma , survivorship curve , demography , epidemiology , retrospective cohort study , ethnic group , population , hazard ratio , proportional hazards model , gerontology , cohort , cohort study , cancer , environmental health , radiation therapy , confidence interval , sociology , anthropology
Objective The literature on nasopharyngeal carcinoma survival in the United States has focused mostly on Whites or Asians and not much is known about survivorship in other minority racial and ethnic groups. We aimed to determine the disease‐specific survival rate and prognostic factors for nasopharyngeal carcinoma survival across the minority United States population. Design A retrospective cohort study. Setting The Surveillance, Epidemiology and End Results ( SEER ) 13 database from 1992 to 2014 was queried for adult cases of nasopharyngeal carcinoma ( n = 2549). Participants Eligible cases were Blacks, Hispanics, Asians/Pacific Islanders, American Indians/Alaska Natives; White patients were excluded. Main Outcomes Measure A multivariable competing risk survival analysis yielded hazard ratios ( HR ) for competing mortality and was used to identify independent prognostic factors for survival. Results Non‐Hispanic American Indians/Alaska Natives consistently had the worst cause‐specific survival of any group and that non‐Hispanic Asians/Pacific Islanders consistently had the best survival ( P < 0.001). Even after adjusting for other poor prognostic factors in the study, including older age, keratinising histology, and lack of radiation treatment, non‐Hispanic American Indians/Alaska Natives had more than double hazards of death from nasopharyngeal cancer compared with non‐Hispanic Asians/Pacific Islanders ( aHR = 2.63, 95% CI 1.67, 4.13). Conclusions There are disparities in nasopharyngeal carcinoma survival among racial and ethnic minority groups in the United States, with American Indians/Alaskan Natives faring worst. It is critical that future research focuses on nasopharyngeal carcinoma among this population to improve survivorship and mitigate cancer‐related health disparities.