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Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004‐2013
Author(s) -
Huang S.J.,
Tang Y.Y.,
Liu H.M.,
Tan G.X.,
Wang X.,
Zhang H.,
Yang F.,
Yang S.
Publication year - 2018
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13124
Subject(s) - medicine , epidemiology , nasopharyngeal carcinoma , surveillance, epidemiology, and end results , retrospective cohort study , marital status , cohort , population , database , ethnic group , stage (stratigraphy) , disease , cohort study , survival analysis , oncology , cancer registry , radiation therapy , paleontology , environmental health , sociology , computer science , anthropology , biology
Objectives To determine the impact of age at diagnosis and other factors on survival in nasopharyngeal carcinoma ( NPC ). Design, Setting and Participants A retrospective, population‐based cohort study of 3103 patients are selected, whose records were submitted to the Surveillance, Epidemiology, and End Results ( SEER ) database between 2004 and 2013. We evaluated the demographic and clinical characteristics of patients who were 20 years or older with a diagnosis of primary, non‐metastatic NPC . Main outcome measures Overall survival ( OS ) and risks of OS and NPC ‐specific survival. Results Overall survival rates at 1, 3, and 5 years were 85.8%, 71.0%, and 62.6%, respectively. Older age was a significant predictor of poor OS , as was Chinese ethnicity. We also determined that middle‐aged white patients, but not middle‐aged black or Chinese patients, were at a higher risk of death than were younger patients of the same race/ethnicity. Nodal (N) stage 0‐1 disease was a significant predictor of poor OS when comparing survival of older patients with N0‐1 vs N2‐3 stage disease. Finally, we found that married patients had a decreased risk of death when compared to those who were single. Conclusions The survival of older patients with NPC is inferior to that of younger patients. Race/ethnicity, marital status, and stage of disease are important modifiers of risk. Collectively, our results indicate that management of older patients requires optimisation.