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Adjuvant radiotherapy in sinonasal mucosal melanoma: A retrospective analysis
Author(s) -
Caspers C.J.I.,
Dronkers E.A.C.,
Monserez D.,
Wieringa M.H.,
Baatenburg de Jong R.J.,
Hardillo J.A.U.
Publication year - 2018
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13033
Subject(s) - medicine , radiation therapy , mucosal melanoma , retrospective cohort study , surgery , adjuvant , multivariate analysis , resection margin , log rank test , stage (stratigraphy) , distant metastasis , survival analysis , metastasis , cancer , resection , head and neck , paleontology , biology
Objectives Evaluation of outcome after curative treatment for sinonasal mucosal melanoma focused on the effect of adjuvant radiotherapy on recurrence and survival. Design Retrospective chart analysis. Setting Tertiary referral hospital. Participants Fifty‐one patients with primary sinonasal mucosal melanoma who underwent surgical resection with curative intention between 1980 and 2016 at Erasmus Medical Center, Rotterdam. Main outcome measures Patients were categorised into 2 groups: surgery alone and surgery with adjuvant radiotherapy. Log‐rank test was used to compare rates of recurrence and survival between treatment groups. Predictors for treatment modality, recurrence and survival were assessed with multivariate statistical analysis. Results Of all patients , 23.5% developed local recurrence and 47.1% developed distant metastasis. Estimated 5‐year disease‐free survival was 25.2%, and 5‐year overall survival (OS) was 38.1%. Forty‐three patients (84.3%) were treated with post‐operative radiotherapy. Patients who underwent surgery with adjuvant radiotherapy presented more often with high tumour stage, tumour involving multiple sites and positive margins. Post‐operative radiotherapy seemed to be associated with better local control ( P = .549). No effect was found on occurrence of distant metastasis and OS. Positive margin status was an independent negative predictor for distant metastasis‐free survival and overall survival. Conclusions Our treatment outcomes are consistent with literature. Post‐operative radiotherapy seems to be associated with improved local control despite advanced disease and positive margin status in this treatment group.