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Clinicopathological relevance of antithyroglobulin antibodies in low‐risk papillary thyroid cancer
Author(s) -
Morand G.B.,
Silva S.D.,
Mlynarek A.M.,
Black M.J.,
Payne R.J.,
Hier M.P.
Publication year - 2017
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12835
Subject(s) - medicine , perioperative , thyroid cancer , papillary thyroid cancer , medical record , thyroiditis , thyroid , surgery
Objective The extent of initial surgical management in papillary thyroid cancer ( PTC ) is controversial. We examined whether the presence of perioperative antithyroglobulin antibodies ( TGA ) could predict long‐term recurrence and occurrence of adverse features among a homogenous group of patients with PTC . Methods The clinical features of patients with PTC treated at a single institution (Jewish General Hospital, McGill University, Montreal, Canada) were obtained from the medical records, and all clinicopathologic information was reviewed. Only low‐risk PTC without clinical evidence of nodal disease before surgery and treated with 30 mCi of radioactive iodine was included in the study. Results The chart review retrieved 361 patients with a median follow‐up of 85.0 months (Q25‐Q75 73‐98). Forty‐two (11.6%) patients had presence of perioperative TGA . Perioperative TGA s were associated with present extrathyroidal extension ( P =.005), unsuspected nodal disease ( P =.001) and autoimmune thyroiditis ( P <.0001). Overall, 17 (4.7%) patients experienced locoregional recurrence. Perioperative TGA s were a significant predictor of recurrence in univariable ( P =.021) but not in multivariable analysis ( P =.13). Conclusion Presence of perioperative TGA s is associated with aggressive histological features and the presence of thyroiditis. Detection of TGA perioperatively may encourage surgeons to consider more extensive initial surgery.