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Association between 24‐hour combined multichannel intraluminal impedance‐ pH monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux
Author(s) -
Kim S.I.,
Kwon O.E.,
Na S.Y.,
Lee Y.C.,
Park J.M.,
Eun Y.G.
Publication year - 2017
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12817
Subject(s) - laryngopharyngeal reflux , medicine , reflux , larynx , heartburn , pharynx , prospective cohort study , quality of life (healthcare) , gastroenterology , esophageal ph monitoring , correlation , cohort , gerd , surgery , disease , nursing , geometry , mathematics
Objective To evaluate the association between the parameters of 24‐hour multichannel intraluminal impedance ( MII )‐ pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux ( LPR ) patients. Design Prospective cohort study without controls. Setting University teaching hospital. Methods Forty‐five LPR patients were selected from subjects who underwent 24‐hour MII ‐ pH monitoring and were diagnosed with LPR from September 2014 to May 2015. Reflux Symptom Index ( RSI ), Health‐related Quality of Life ( HRQ oL), Short Form 12 ( SF ‐12) Survey questionnaires were surveyed. Spearman's correlation was used to analyse the association between the symptoms or QoL and 24‐hour MII ‐ pH monitoring. Results Most parameters in 24‐hour MII ‐ pH monitoring showed weak or no correlation with RSI , HRQ oL and SF ‐12. Only number of non‐acid reflux events that reached the larynx and pharynx ( LPR ‐non‐acid) and number of total reflux events that reached the larynx and pharynx ( LPR ‐total) parameters showed strong correlation with heartburn in RSI ( R = 0.520, P < 0.001, R = 0.478, P = 0.001, respectively). Multiple regression analysis showed that there was only one significant regression coefficient between LPR ‐non‐acid and voice/hoarseness portion of HRQ oL ( b = 1.719, P = 0.022). Conclusion Most parameters of 24‐hour MII ‐ pH monitoring did not reflect subjective symptoms or QoL in patients with LPR .