Premium
Postoperative value of serum squamous cell carcinoma antigen as a predictor of recurrence in sinonasal inverted papilloma
Author(s) -
Zijl F.V.W.J.,
Monserez D.A.,
Korevaar T.I.M.,
Bugter O.,
Wieringa M.H.,
Baatenburg de Jong R.J.,
Hardillo J.A.U.
Publication year - 2017
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12757
Subject(s) - medicine , otorhinolaryngology , inverted papilloma , retrospective cohort study , basal cell , surgery , cohort , oncology , papilloma , pathology
Objectives Sinonasal inverted papilloma ( IP ) has several unfavourable characteristics and therefore requires careful monitoring. The goal of this study was to identify whether serum squamous cell carcinoma antigen ( SCC a) could predict IP recurrence. Design A retrospective cohort study. Setting Department of otolaryngology/head and neck surgery, Erasmus Medical Centre, Rotterdam, the Netherlands. Participants One hundred and thirty patients with IP treated at our centre with SCC a measurements available were included. Main outcome measurements Follow‐up of patients with IP since 2005, recurrence was defined as new disease within primary localisation at least 3 months after adequate surgical removal. We analysed the association between IP recurrence and serum SCC a values measured preoperatively, postoperatively and during follow‐up. Results Preoperative SCC a values or values measured during follow‐up were not associated with risk of recurrence. Postoperative SCC a was positively associated with the risk of recurrence ( P < 0.001). Postoperative SCC a had a good discriminative ability for the identification of recurrence with an area under the curve of 80.9%. Conclusion Postoperative SCC a is strongly associated with risk of recurrence. This might help the surgeon in the postoperative setting by identifying high‐risk patients and planning follow‐up strategy tailored to the individual patient.