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The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations
Author(s) -
Lou Z.,
Lou Z.,
Tang Y.,
Xiao J.
Publication year - 2016
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12564
Subject(s) - medicine , ofloxacin , eardrum , surgery , tympanic membrane perforation , anesthesia , genetics , radiology , ciprofloxacin , bacteria , biology
Objective To investigate the effects of direct application of ofloxacin otic drops on human traumatic tympanic membrane perforations ( TMP s). Study design Prospective, sequential allocation, controlled clinical study. Setting Tertiary university hospital. Participants In total, 149 patients with traumatic TMP s were recruited. They were allocated sequentially to two groups: a conservative observation group ( n = 75) and a ofloxacin drops‐treated group ( n = 74). Main outcome measures The closure rate, closure time and rate of otorrhoea were compared between the groups at 6 months. Results In total, 145 patients were analysed. The closure rates of medium perforations between the groups were not significantly different ( P = 0.35); however, the ofloxacin drops‐treated group had a significantly shorter closure time for medium perforations than the observation group ( P < 0.01). Additionally, the ofloxacin drops‐treated group showed improvement in the closure rate of large perforations ( P = 0.02) and a significantly shorter mean closure time ( P < 0.01) than the observation group. However, purulent otorrhoea was not significantly different between the groups ( P = 0.37). Conclusions The present findings indicate that the moist eardrum environment resulting from topical application of ofloxacin drops shortened the closure time and improved the closure rate, but did not affect hearing improvement or increase the rate of middle ear infection of large traumatic TMP s. Thus, although traumatic TMP s tend to heal spontaneously, moist therapy can be considered for traumatic, large TMP s in the clinic.