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Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single‐blinded trial
Author(s) -
Park D.Y.,
Chung H.J.,
Sim N.S.,
Jo K.H.,
Kim D.H.,
Kim C.H.,
Yoon J.H.
Publication year - 2016
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12505
Subject(s) - medicine , carboxymethyl cellulose , nasal packing , surgery , endoscopic sinus surgery , calcium , functional endoscopic sinus surgery , prospective cohort study , visual analogue scale , calcium alginate , anesthesia , sinus (botany) , randomized controlled trial , sinusitis , chemistry , botany , organic chemistry , genus , biology , sodium
Objectives Calcium alginate is a biodegradable gel‐transforming agent widely used for nasal packing. It can reduce pain and improve comfort. However, few randomised controlled trials have compared the efficacy of calcium alginate nasal packing with that of other biodegradable gel‐transforming materials. Design Prospective, randomised, single‐blinded controlled study. Setting Yonsei University Severance Hospital, a tertiary academic medical centre. Participants Twenty‐seven patients (54 nostrils) with chronic rhinosinusitis who were scheduled for bilateral endoscopic sinus surgery were enrolled. After surgery, one nostril was packed with calcium alginate and the other with carboxymethyl cellulose. Only patients with an intersinus chronic rhinosinusitis severity score difference of ≤1 were included. Main outcome measures Visual analogue scale ( VAS ) scores for postoperative pain, discomfort from nasal discharge and pain during packing removal were analysed. Two independent rhinologists who were blinded to the assessments separately scored adhesions, oedema and infection by endoscopic digital photography at 1, 4 and 8 weeks postoperatively. Results There were no significant differences in VAS scores for postoperative pain, discomfort from nasal discharge or pain during packing removal between calcium alginate packings and carboxymethyl cellulose packings. Inter‐rater variability of adhesion, oedema and infection scores was acceptable. Adhesion severity and oedema scores at 4 weeks were significantly lower with calcium alginate packing than with carboxymethyl cellulose. Infection severity scores also tended to be lower with calcium alginate than with carboxymethyl cellulose, but the difference was not significant. Conclusions Calcium alginate nasal packing is associated with reduced severity of oedema and adhesions after endoscopic sinus surgery.