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Differential expression of LOXL 4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma
Author(s) -
Yilmaz M.,
Suer I.,
Karatas O.F.,
Cansiz H.,
Ozen M.
Publication year - 2016
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12498
Subject(s) - medicine , metastasis , pathology , cancer , carcinoma , laryngeal neoplasm , head and neck cancer , oncology
Objective Head and neck cancer is the sixth most common cancer in worldwide with an increasing incidence rate in recent years. LOXL 4 is expressed in several tissues, and its expression has been shown to display a significant correlation with local lymph node metastasis. In this study, we aimed to explore the LOXL 4 expression level in metastatic and non‐metastatic LSCC tissues and to determine its prognostic significance. Study design Basic science research study. Setting University hospital. Participants A total of 40 patients were included in the study. Main outcome measure LOXL 4 expression status in metastatic, non‐metastatic LSCC and normal tissue samples was investigated by quantitative reverse‐transcription PCR . Results We demonstrated that LOXL 4 was significantly overexpressed in LSCC tumour tissue samples in comparison with the corresponding normal tissues ( P < 0.001); however, no significant relationship has been found between LOXL 4 expression and either the metastatic potential or the T classification of the specimens. Conclusions Although expression of LOXL 4 is not statistically associated with neck metastases, we showed that LOXL 4 expression significantly increased in laryngeal cancer.