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Survival outcome of patients with nasopharyngeal carcinoma: a nationwide analysis of 13 407 patients in Taiwan
Author(s) -
Huang W.Y.,
Lin C.L.,
Lin C.Y.,
Jen Y.M.,
Lo C.H.,
Sung F.C.,
Kao C.H.
Publication year - 2015
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.12371
Subject(s) - medicine , nasopharyngeal carcinoma , proportional hazards model , multivariate analysis , retrospective cohort study , cohort , radiation therapy , population , demography , environmental health , sociology
Objectives We reported the contemporary survival outcome of patients with nasopharyngeal carcinoma (NPC) and analysed the factors affecting survival. Design A retrospective cohort study. Setting A nationwide population‐based study in Taiwan. Participants We identified 13 407 patients with newly diagnosed NPC from 2002 to 2010. Material and Methods The multivariate Cox proportional hazards model was performed to measure the mortality‐association risk factor in patients with NPC after adjusting for NPC treatment and socio‐demographic characteristics. Results The 1‐, 2‐, 5‐ and 8‐year overall survival ( OS ) rates were 89.6%, 80.4%, 65.2% and 56.5%, respectively. The factors associated with mortality risk were sex (men versus women, HR = 1.45), age (>60 versus ≤ 40 years, HR = 3.61), geographic region of residence (eastern Taiwan versus northern Taiwan HR = 1.39), income (<15 840 versus >25 000, HR = 1.87) and treatment modality (chemotherapy alone versus radiotherapy alone, HR = 2.25). Conclusion The contemporary 5‐year OS rate was 65.2% in Taiwan. Male patients, old age, residing in eastern Taiwan, low income and receiving chemotherapy alone were independent predictors for poor OS .