Open AccessEfficacy and safety of 3‐n‐butylphthalide for the treatment of cognitive impairment: A systematic review and meta‐analysis
Author(s) -
Zhou Qiulu,
Han Chao,
Xia Yun,
Wan Fang,
Yin Sijia,
Li Yunna,
Kou Liang,
Chi Xiaosa,
Hu Junjie,
Sun Yadi,
Wu Jiawei,
Zou Wenkai,
Huang Jinsha,
Wang Tao
Publication year - 2022
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13952
Subject(s) - cochrane library , meta analysis , cognition , randomized controlled trial , medicine , montreal cognitive assessment , cognitive impairment , medline , clinical trial , adverse effect , scopus , clinical psychology , psychiatry , political science , law
Background Current evidence for the efficacy of pharmacological treatment in improving cognitive function is absent. Recent studies have reported that 3‐n‐butylphthalide (NBP) has a positive effect on improving cognitive impairment; however, its clinical efficacy and safety is unclear. Therefore, we conducted a meta‐analysis to assess its efficacy and safety for cognitive impairment. Methods We systematically searched the PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases, and two reviewers independently screened and extracted the data from included studies. We synthesized the data using the Review Manager Software version 5.3. Results We included six randomized clinical trials (RCTs), encompassing 851 patients with cognitive impairment. The results showed that NBP improved cognitive impairment. Specifically, the clinical efficacy was better than that in the control group, with better performance in improving the Mini‐Mental State Examination and the Montreal Cognitive Assessment scores, while decreasing the Alzheimer's Disease Assessment Scale‐Cognitive subscale and the Clinician's Interview‐Based Impression of Change plus caregiver input scores. There was no significant difference in the incidence of adverse events between both groups. Conclusion The NBP is effective and safe in improving cognitive impairment; however, more high‐quality RCTs are needed to confirm these findings.