Open AccessHypothalamic‐related neural mechanism in lifelong premature ejaculation and trends following selective serotonin reuptake inhibitor administration
Author(s) -
Geng Bowen,
Gao Ming,
Xu Ke,
Zhang Shuming,
Liu Peng
Publication year - 2022
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13882
Subject(s) - premature ejaculation , serotonin reuptake inhibitor , hypothalamus , reuptake inhibitor , serotonin , medicine , serotonin uptake inhibitors , pharmacology , neuroscience , psychology , fluoxetine , receptor , psychoanalysis
Lifelong premature ejaculation patients had altered structural and functional parameters of the hypothalamus compared with healthy controls. The patients showed increased hypothalamus‐related functional connectivity in several regions one hour after dapoxetine administration. The changing trends of the brain functional connectivity after dapoxetine administration possibly provided important information about the selective serotonin reuptake inhibitor effects on the functional neural system.