Open AccessEffects of cognitive reserve proxies on cognitive function and frontoparietal control network in subjects with white matter hyperintensities: A cross‐sectional functional magnetic resonance imaging study
Author(s) -
Ye Qing,
Zhu Huahong,
Chen Huiping,
Liu Renyuan,
Huang Lili,
Chen Haifeng,
Cheng Yue,
Qin Ruomeng,
Shao Pengfei,
Xu Hengheng,
Ma Junyi,
Xu Yun
Publication year - 2022
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13824
Subject(s) - hyperintensity , cognitive reserve , cognition , functional magnetic resonance imaging , psychology , working memory , neuropsychology , association (psychology) , white matter , effects of sleep deprivation on cognitive performance , audiology , dorsolateral prefrontal cortex , magnetic resonance imaging , frontal lobe , cross sectional study , prefrontal cortex , physical medicine and rehabilitation , medicine , neuroscience , cognitive impairment , pathology , radiology , psychotherapist
Aims This study aimed to analyze the potential association between cognition reserve (CR) components, including education, working activity, and leisure time activity, and cognitive function in subjects with white matter hyperintensities (WMH). The study also explored the role of the frontoparietal control network (FPCN) in such association. Methods White matter hyperintensities subjects with and without cognitive impairment (CI) were evaluated with multimodal magnetic resonance imaging, neuropsychological testing, and CR survey. FPCN patterns were assessed with dorsolateral prefrontal cortex seed‐based functional connectivity analysis. Results Education was positively associated with cognitive function in WMH subjects with or without CI, whereas working activity and leisure time activity were positively associated with cognitive function only in those without CI. Similarly, education was associated with bilateral FPCN in both WMH groups, whereas working activity and leisure time activity were associated with bilateral FPCN mainly in the group without CI. Furthermore, FPCN partially mediated the association between education and cognitive function in both WMH groups. Conclusion Education showed a positive impact on cognitive function in WMH subjects regardless of their cognitive status, whereas working activity and leisure time activity exhibited beneficial effects only in those without CI. The FPCN mediated the beneficial effect of education on cognitive function.