Open Access18 F‐fluorodeoxy‐glucose positron emission tomography pattern and prognostic predictors in patients with anti‐GABAB receptor encephalitis
Author(s) -
Liu Xiao,
Yu Tingting,
Zhao Xiaobin,
Li Gongfei,
Lv Ruijuan,
Ai Lin,
Wang Qun
Publication year - 2022
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13767
Subject(s) - hypermetabolism , positron emission tomography , encephalitis , medicine , temporal lobe , gabab receptor , nuclear medicine , pathology , gastroenterology , epilepsy , receptor , immunology , virus , psychiatry , antagonist
Aims To identify the metabolic pattern and prognostic predictors in anti‐gamma‐aminobutyric‐acid B (GABAB) receptor encephalitis using 18 F‐fluorodeoxy‐glucose positron emission tomography ( 18 F‐FDG‐PET). Methods Twenty‐one patients diagnosed anti‐GABAB receptor encephalitis who underwent 18 F‐FDG‐PET at first hospitalization were retrospectively reviewed. 18 F‐FDG‐PET images were analyzed in comparison with controls. Further group comparisons of 18 F‐FDG‐PET data were carried out between prognostic subgroups. Results 18 F‐FDG‐PET was abnormal in 81% patients with anti‐GABAB receptor encephalitis and was more sensitive than MRI (81% vs. 42.9%, p = 0.025). Alter limbic lobe glucose metabolism (mostly hypermetabolism) was observed in 14 patients (66.7%), of whom 10 (10/14, 71.4%) demonstrated hypermetabolism in the medial temporal lobe (MTL). Group analysis also confirmed MTL hypermetabolism in association with relative frontal and parietal hypometabolism was a general metabolic pattern. After a median follow‐up of 33 months, the group comparisons revealed that patients with poor outcome demonstrated increased metabolism in the MTL compared to those with good outcome. Conclusion 18 F‐FDG‐PET may be more sensitive than MRI in the early diagnosis of anti‐GABAB receptor encephalitis. MTL hypermetabolism was associated with relative frontal or parietal hypometabolism and may serve as a prognostic biomarker in anti‐GABAB receptor encephalitis.