Open AccessInduced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
Author(s) -
Ma Yizhao,
Xu Xiaonan,
Li Chunhong,
Wang Yi,
Zhu Jie,
Xia Xiaohuan,
Zheng Jialin C.
Publication year - 2021
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13744
Subject(s) - progenitor cell , microbiology and biotechnology , mapk/erk pathway , extracellular , neural stem cell , protein kinase b , kinase , signal transduction , chemistry , apoptosis , biology , stem cell , biochemistry
Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regulated kinase (ERK), but not AKt. The EV‐induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation.