Open AccessLarge‐scale whole‐exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder
Author(s) -
Zhou Wei,
Chen Luan,
Jiang Bixuan,
Sun Yidan,
Li Mo,
Wu Hao,
Zhang Na,
Sun Xiaofang,
Qin Shengying
Publication year - 2021
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13733
Subject(s) - christian ministry , china , library science , medicine , political science , law , computer science
In the present study, we performed an exome‐wide investigation of the burden of rare disease‐causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene‐based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease‐causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.