Open AccessNormobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies
Author(s) -
Ding JiaYue,
Liu Yu,
Rajah GaryB.,
Chen ZhiYing,
Zhang ShiYong,
Ding YuChuan,
Ji XunMing,
Meng Ran
Publication year - 2021
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13703
Subject(s) - electroencephalography , alpha (finance) , eeg fmri , medicine , beta (programming language) , delta rhythm , anesthesia , neuroscience , psychology , alpha rhythm , surgery , computer science , construct validity , patient satisfaction , programming language
Aims To explore the safety and efficacy of normobaric oxygen (NBO) on correcting chronic cerebral ischemia (CCI) and related EEG anomalies. Methods This prospective randomized trial (NCT03745092) enrolled 50 cases of CCI patients, which were divided into NBO (8 L/min of oxygen supplement) group and control group (room air) randomly, and also enrolled 21 healthy volunteers. Two times of 30‐min EEG recordings with the interval of 45min of NBO or room air were analyzed quantitatively. Results The CCI‐mediated EEG presented with two patterns of electrical activities: high‐power oscillations (high‐power EEG, n = 26) and paroxysmal slow activities under the normal‐power background (normal‐power EEG, n = 24). The fronto‐central absolute power (AP) of the beta, alpha, theta, and delta in the high‐power EEG was higher than that in healthy EEG ( p < 0.05). The fronto‐central theta/alpha, delta/alpha and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG were higher than those in healthy EEG ( p < 0.05). The high‐power EEG in NBO group had higher fronto‐central AP reduction rates than those in control group ( p < 0.05). NBO remarkably reduced the fronto‐central theta/alpha, delta/alpha, and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG ( p < 0.05). Conclusions NBO rapidly ameliorates CCI‐mediated EEG anomalies, including attenuation of the abnormal high‐power oscillations and the paroxysmal slow activities associated with CCI.