Open AccessAlterations in intrinsic functional networks in Parkinson’s disease patients with depression: A resting‐state functional magnetic resonance imaging study
Author(s) -
Qiu YiHui,
Huang ZhiHeng,
Gao YuYuan,
Feng ShuJun,
Huang Biao,
Wang WanYi,
Xu QiHuan,
Zhao JieHao,
Zhang YuHu,
Wang LiMin,
Nie Kun,
Wang LiJuan
Publication year - 2021
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13467
Subject(s) - functional magnetic resonance imaging , posterior cingulate , resting state fmri , neuroscience , parahippocampal gyrus , depression (economics) , prefrontal cortex , psychology , parkinson's disease , anterior cingulate cortex , magnetic resonance imaging , medicine , disease , temporal lobe , radiology , cognition , economics , epilepsy , macroeconomics
Abstract Aims The aim of this research was to investigate the alterations in functional brain networks and to assess the relationship between depressive impairment and topological network changes in Parkinson's disease (PD) patients with depression (DPD). Methods Twenty‐two DPD patients, 23 PD patients without depression (NDPD), and 25 matched healthy controls (HCs) were enrolled. All participants were examined by resting‐state functional magnetic resonance imaging scans. Graph theoretical analysis and network‐based statistic methods were used to analyze brain network topological properties and abnormal subnetworks, respectively. Results The DPD group showed significantly decreased local efficiency compared with the HC group ( P = .008, FDR corrected). In nodal metrics analyses, the degree of the right inferior occipital gyrus ( P = .0001, FDR corrected) was positively correlated with the Hamilton Depression Rating Scale scores in the DPD group. Meanwhile, the temporal visual cortex, including the bilateral middle temporal gyri and right inferior temporal gyrus in the HC and NDPD groups and the left posterior cingulate gyrus in the NDPD group, was defined as hub region, but not in the DPD group. Compared with the HC group, the DPD group had extensive weakening of connections between the temporal‐occipital visual cortex and the prefrontal‐limbic network. Conclusions These results suggest that PD depression is associated with disruptions in the topological organization of functional brain networks, mainly involved the temporal‐occipital visual cortex and the posterior cingulate gyrus and may advance our current understanding of the pathophysiological mechanisms underlying DPD.