Open AccessBidirectional Brain‐gut‐microbiota Axis in increased intestinal permeability induced by central nervous system injury
Author(s) -
Li Xiaojin,
You Xinyu,
Wang Congying,
Li Xueli,
Sheng Yuanyuan,
Zhuang Pengwei,
Zhang Yanjun
Publication year - 2020
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13401
Subject(s) - central nervous system , intestinal permeability , enteric nervous system , gut–brain axis , immune system , gut flora , context (archaeology) , nervous system , autonomic nervous system , inflammation , biology , neuroscience , medicine , immunology , endocrinology , paleontology , heart rate , blood pressure
Central nervous system injuries may lead to the disorders of the hypothalamic‐pituitary‐adrenal axis, autonomic nervous system, and enteric nervous system. These effects then cause the changes in the intestinal microenvironment, such as a disordered intestinal immune system as well as alterations of intestinal bacteria. Ultimately, this leads to an increase in intestinal permeability. Inflammatory factors produced by the interactions between intestinal neurons and immune cells as well as the secretions and metabolites of intestinal flora can then migrate through the intestinal barrier, which will aggravate any peripheral inflammation and the central nervous system injury. The brain‐gut‐microbiota axis is a complex system that plays a crucial role in the occurrence and development of central nervous system diseases. It may also increase the consequences of preventative treatment. In this context, here we have summarized the factors that can lead to the increased intestinal permeability and some of the possible outcomes.