Open AccessMitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure
Author(s) -
Wang Yan,
Xu Erin,
Musich Phillip R.,
Lin Fang
Publication year - 2019
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.13116
Subject(s) - mitophagy , pink1 , mitochondrion , parkin , mitochondrial biogenesis , ampk , microbiology and biotechnology , biogenesis , neuroscience , biology , autophagy , medicine , parkinson's disease , genetics , apoptosis , kinase , protein kinase a , disease , gene
Summary Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria in aging and neurodegenerative diseases, and the signaling pathways leading to mitochondrial biogenesis (including PGC‐1 family proteins, SIRT1, AMPK) and mitophagy (parkin‐Pink1 pathway). Understanding the regulation of these mitochondrial pathways may be beneficial in finding pharmacological approaches or lifestyle changes (caloric restrict or exercise) to modulate mitochondrial biogenesis and/or to activate mitophagy for the removal of damaged mitochondria, thus reducing the onset and/or severity of neurodegenerative diseases.